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Senior Research Associate - Chemical Biology and Molecular Cell Biology of Cancer

Biomedical & Life Sciences
Salary:   £34,804 to £40,322
Closing Date:   Wednesday 27 November 2019
Interview Date:   Monday 16 December 2019
Reference:  A2840

We are looking for a postdoctoral researcher to join our team to investigate novel methods to degrade centrosome clustering proteins in cancer cells. 

This is a 24-month fixed-term position in the first instance, with the possibility for extension. The project is funded by a North West Cancer Research Cancer Discovery grant, jointly awarded to Dr Morgan Gadd and Dr Andrew Fielding in the Division of Biomedical and Life Sciences at Lancaster University, UK. It is titled “Small molecule induced degradation of centrosome clustering proteins: development of a novel, cancer-specific therapeutic approach.”

You will utilise cutting-edge genetics and chemical biology methods in order to target key centrosome clustering proteins. In particular you will be responsible for designing proteolysis-targeting chimaeras (PROTACs) that will cause degradation of their protein target. These developments will lead to a greater understanding of how targeting these proteins are relevant to the biology of cancers of prominence in the North West, as well as provide the first steps towards discovering therapeutically relevant degraders for our promising targets.

Candidate requirements:

  • A PhD awarded (or soon to be awarded) in a relevant field.

  • A strong background in chemical biology and/or molecular and cell biology.

  • Some experience in synthetic or medicinal chemistry.

  • Experience with mammalian cell culture, plasmid design and CRISPR.

  • An interest in targeted protein degradation and/or cancer drug discovery would be advantageous.

  • Ability to solve problems creatively and plan and work independently, but also work in and/or manage a team when required.

  • Excellent communication and presentation skills, both for communicating within the scientific community and to various audiences in the community as a part of outreach activities.

Our labs in the Division of Biomedical and Life Sciences constitute part of a large and vibrant cancer research grouping. The division is a friendly research environment that strongly supports the individual needs of each employee and which actively promotes a healthy work-life balance.

The Faculty of Health and Medicine is committed to family-friendly and flexible working policies. For example, we are willing to consider flexible or condensed hours for this post. The Faculty has held a Silver Athena SWAN award since 2014 in recognition of its good employment practice undertaken to address gender equality in higher education and research.

In 2018, Lancaster University was named University of the Year by The Times and The Sunday Times Good University Guide whilst recently, in the 2020 guide, has been named International University of the Year.

Informal enquiries are welcome and encouraged. Please contact: Dr Morgan Gadd ( ), Dr Andrew Fielding ( or Dr Sarah Allinson ( for more information.

We welcome applications from people in all diversity groups

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

Further details:

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